Drak1
Web30 nov 1998 · Overexpression of DRAK1 and DRAK2 induces the morphological changes associated with apoptosis. NIH 3T3 cells were co-transfected with expression vectors for DRAKs together with LacZ as an indicator of the transfection. After 36 h, transfected cells were visualized by staining with X-gal solution. Web19 set 2005 · DRAK1 and DRAK2 both contain strong consensus sequences for NLSs present near the kinase active site. DAPK3 and DAPK1 also contain such NLS motifs in this region, though DAPK1 is not normally localized in the nucleus as a result of retention by cytoskeletal proteins outside of this organelle ( 3 , 28 ).
Drak1
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WebDRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1; also STK17A) is a 55 kDa member of the DAP kinase subfamily, CAMK Ser/Thr protein kinase family of enzymes. It is expressed in osteoclasts, resides in the nucleus, and initiates apoptosis. Human DRAK1 is 414 amino acids (aa) in length. It contains an N-terminal polyPro segment (aa ... Web1 lug 2024 · DRAK1 bounds directly to the TRAF domain of TRAF6, preventing its autoubiquitination by interfering homo-oligomerization, eventually leading to autophagy-mediated degradation of TRAF6. Depletion of DRAK1 in cervical cancer cells resulted in markedly increased levels of TRAF6 protein, promoting activation of the IL1β signaling …
WebDRAK1 IC50 (μM) DAPK1 IC50 (μM) DAPK3 IC50 (μM) TRD-93 0.16 1.4 >10 >10 FIGURE 4 Predicted docking pose of ligands in the ligand binding site of DRAK2 (3LM0). Color of Ligand carbon atoms are assigned from green to white with respect to activity respectively. TRD-93 is depicted in thick magenta sticks. PARK ET AL. BULLETIN OF THE 3 … Web1 ott 2014 · DRAK1 specifically binds to Smad3 through its kinase domain, thereby blocking recruitment of Smad4 and translocation of Smad3 into nucleus. Thus, our findings suggest that aberrant expression of DRAK1 increases tumorigenic potential through the inhibition of TGF-β1 tumor suppressor activity in head and neck cancer cells.
Web22 feb 2024 · Furthermore, DRAK1 was markedly underexpressed in chemoresistant cervical cancer patient tissues compared with chemosensitive samples. We found that …
Web22 dic 2014 · DRAK1 is significantly overexpressed in HNSCC cells. (a) Heatmap of published microarray data sets of the expression levels of DRAK1 in normal and HNSCC …
WebC Cell viability assay of DRAK1-knockdowned HeLa cells upon paclitaxel treatment ranging from 2.5 to 40 nM. The data represent the mean ± S.D. of three independent experiments. *p < 0.05; ... peking chinese restaurant suwaneeWeb22 feb 2024 · Furthermore, DRAK1 was markedly underexpressed in chemoresistant cervical cancer patient tissues compared with chemosensitive samples. We found that DRAK1 protein was destabilized through K48-linked polyubiquitination promoted by the Cullin scaffold protein 3 (CUL3) / speckle-type POZ (poxvirus and zinc finger protein) … mechanic actionWeb13 apr 2024 · See new Tweets. Conversation. Maveriq.Gunpla mechanic advertsWeb22 feb 2024 · Furthermore, DRAK1 was markedly underexpressed in chemoresistant cervical cancer patient tissues compared with chemosensitive samples. We found that DRAK1 protein was destabilized through K48-linked polyubiquitination promoted by the Cullin scaffold protein 3 (CUL3) / speckle-type POZ (poxvirus and zinc finger protein) … mechanic airslider 45Web17 gen 2024 · 7QUE, 7QUF. PubMed Abstract: Serine/threonine kinase 17A (death-associated protein kinase-related apoptosis-inducing protein kinase 1─DRAK1) is a part of the death-associated protein kinase (DAPK) family and belongs to the so-called dark kinome. Thus, the current state of knowledge of the cellular function of DRAK1 and its … mechanic adjustable creeperWeb17 gen 2024 · 7QUE, 7QUF. PubMed Abstract: Serine/threonine kinase 17A (death-associated protein kinase-related apoptosis-inducing protein kinase 1─DRAK1) is a part … mechanic aesthetic outfitsWebDRAK1 Protein, active, 250 µg Active, N-terminal 6His-tagged, recombinant, full length human DRAK1, for use in Kinase Assays. - Find MSDS or SDS, a COA, data sheets and … peking chinese restaurant three forks