Photolabile linkers for solid-phase synthesis
WebJul 28, 1997 · The versatility of photolabile linkers was evidenced by the synthesis of oligo- nucleotides with a 3'-amino or carboxylic acid function13,14. Cleavage from the support … WebMar 1, 2004 · We have designed a new photolabile linker (2) based on 2-pivaloylglycerol for the solid-phase synthesis of acids. The linker was prepared in six steps and anchored to …
Photolabile linkers for solid-phase synthesis
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WebLinkers for Fmoc SPPS Novabiochem ® has one of the most extensive ranges of linkers and derivatized resins for Fmoc solid phase peptide synthesis. The properties of these resins … WebJun 4, 2024 · We have designed a new photolabile linker (2) based on 2-pivaloylglycerol for the solid-phase synthesis of acids. The linker was prepared in six steps and anchored to the support via an amide bond.
WebDownload Citation A photolabile ‘traceless’ linker for solid-phase organic synthesis A photolabile linker based on a thiohydroxamic acid has been shown to be an efficient ‘traceless ... WebPhotolabile Resins; Multifunctional Resins; REAGENTS. Coupling Reagents; ... Linker for Solid Phase Peptide Synthesis; Cleavable Linker - Val-Ala based; Cleavable Linker - Val-Cit based ... solvents, and scavengers for solid phase chemistry as well as reagents for attaching protecting groups and further useful agents. View products.
WebOct 23, 2009 · About this book. Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely ... WebThis communication presents the synthesis of a novel photolabile azidolinker based on the o-nitroveratryl group. The application of this linker for the synthesis and photolytic release of NH-1,2,3-triazoles is described. ... A photolabile linker for the solid-phase synthesis of 4-substituted NH-1,2,3-triazoles ...
WebJan 1, 2024 · Synthesis of photocleavable linkers9.4.1. Functionalization of ortho-nitrobenzyl linkers. The literature discusses a large number of methods for ONB linker chemistry [33, 35, 69, 76, 78, 80, 83, 88]. Most of these relate to the synthesis of photocaged small drug or ligand molecules or application of light-cleavable linkers in solid-phase ...
WebMar 7, 2024 · Alternate Names: Fmoc-Photo-Linker is also known as Fmoc-Photolabile Linker. Application: Fmoc-Photo-Linker is an Fmoc-amino photolabile-linker used in the solid-phase synthesis of peptide amides. CAS Number: 162827-98-7 simple project planning software freeWebSince Gomberg’s discovery of radicals as chemical entities, the interest around them has increased through the years. Nowadays, radical chemistry is used in the synthesis of 75% of all polymers, inevitably establishing a close relationship with Solid-Phase Organic Synthesis. More recently, the interest of organic chemists has shifted towards the application of … simple project planning appWebThis has been functionalized with a photolabile linker group (Pll), followed by a peptide chain (Mis) to increase the sensitivity of the structure to mass spectrometry analyses in MALDI mode. ... Arora, P.S. Solution–and solid-phase synthesis of triazole oligomers that display protein-like functionality. J. Org. Chem. 2007, 72, 7963–7967 ... simple project planningWebNov 10, 1997 · Photolabile linkers have become an important orthogonal technique for substrate cleavage off the resin in solid-phase organic synthesis. Herein, we report an improved synthesis and selective coupling of a hydroxy based photolinker to a hydroxy based solid-phase resin, thereby removing the necessity for protection or on-resin … simple project planning template excelWebSix new photolabile linkers have been developed which allow coupling of building blocks with a carboxy, amino, hydroxy and sulfonyl group. Photolytic cleavage of these building … simple projector for tracingWebApr 17, 2003 · [reaction: see text] A sequential solid-phase peptide synthesis was developed using both photolabile linker and protecting groups. The chromatic sequential lability between a tert-butyl ketone-derived linker (sensitive to irradiation at 305 nm) and a nitroveratryloxycarbonyl (NVOC) group (sensitive at 360 nm) was exploited to prepare Leu … simple projector at homeWebJan 1, 2001 · We have designed a new photolabile linker (2) based on 2-pivaloylglycerol for the solid-phase synthesis of acids. The linker was prepared in six steps and anchored to the support via an amide bond. raybern company of massachusetts