WebFeb 8, 2011 · About 75% of the BAs in mouse liver were conjugated with taurine, approximately 24% unconjugated, whereas only about 0.2% was conjugated with glycine. … WebJan 19, 2024 · The taurine-conjugated TGR5 agonist tauro-RO5527239 did not stimulate secretion of PYY from L-cells, whereas the unconjugated form did. Conjugated forms of …
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WebMay 25, 2024 · The more hydrophilic glyco- and tauro-conjugates of these BAs exhibited less damaging effects. Ursodeoxycholic acid (UDCA) and its conjugates had the lowest mitochondrial toxicity index [ 30 ]. Figure 1 schematically shows the interaction of BAs with various cellular molecules. WebFeb 12, 2024 · Indeed, Lactobacillus have BSHs activity for catalyzing deconjugation of tauro-conjugated BAs . Increased amounts of secondary BAs in the blood may enter the brain through the permeability of the BBB and affect brain physiology and metabolism . DCA represent aetiological agents and mediators of the pathogenic process [98, 99]. papillary constriction
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Webwhich preferentially hydrolyze glyco-conjugated BAs. Few enzymes preferentially hydrolyze tauroconjugates or both glyco- and tauro-conjugated BAs [24]. As a key mediator of BA trans-formations, BSHs have been considered a promising target for the rational manipulation of the gut microbiota to benefit host physiology [21]. WebAug 26, 2024 · Glyco-conjugated BAs exhibited a lower CMC than tauro-conjugated BAs (3.64 compared to 4.0 mM, respectively) (Figs. 6B and 3A). Consistent with this … WebJul 24, 2024 · Free BAs tend to react faster than their glyco- or tauro-conjugated analogues, except for the most strongly reacting GCA. Importantly, we identified a group of poorly reacting BAs (mostly muricholic acids (MCAs) carrying hydroxyl group in position 6β), whose signal during enzymatic determination only reaches about 30% of what is expected. papillary cord